Anti-diabetic

diabetes glucose meter

Palo azul "had good anti-diabetic potential" 

Various clinical studies have shown that palo azul may have anti-diabetic potential because it has shown the ability to promote healthy levels of blood glucose and insulin sensitivity. A 2021 study found that palo azul extracts "demonstrated a significant decrease in fasting blood glucose level." 

study which supports this finding, concluded that extracts from palo azul "significantly decreased blood glucose levels in mice." Another 2018 study concluded that palo azul had good anti-diabetic activity.”

The same 2021 study also concluded that palo azul's extracts "had good antidiabetic potential and could be an appropriate nanomedicine to prevent the development of diabetes." 

The 2018 study similarly concluded the following: “The results indicate that EP (palo azul) has good antidiabetic activity and therefore could be used to prevent the development of diabetes.

women weightlifting

Interestingly, a 2016 study ended with the following statement: "In conclusion, palo azul may increase muscle mass in the body and improve insulin resistance conditions.” 

In addition, it is well documented that oxidative stress can cause cancer, diabetes, cardiovascular disease, and aging. Therefore, a medical review concluded that antioxidants such as antioxidants can “interfere with radical-producing systems and increase the function of endogenous antioxidants, protecting the cells from damage by these free radicals.” 

palo azul flavonoids

The previously cited 2021 study also mentions that "The root cause of diabetes is mainly associated with oxidative stress" and palo azul tea "can reduce the oxidative stress because of its free radical scavenging activity." Lastly, this study found that palo azul "showed marked inhibition in insulin secretion."

What is oxidative stress?

Oxidative stress is an imbalance between free radicals and antioxidants in the body. 2021 study found that palo azul tea "can reduce the oxidative stress caused by the imbalance between reactive oxygen species (ROS) because of its free radical scavenging activity."

oxidative stress

What are free radicals?

Free radicals are atoms with a single valence electron that cause damage to the body associated with diabetes, cancer, aging, atherosclerosis, Parkinson's, Alzheimer's and many other diseases.

free radicals and oxidative stress formation

This happens because electrons like to be in pairs... and for this reason, free radicals look for "free" electrons in the body. This causes damage to cells, proteins, DNA and these damaged molecules can mutate, grow tumors, and damage the DNA code. Eventually, this cellular damage causes new cells to grow with defects and it will lead to aging and degenerative diseases. 

 

palo azul flavonoids

Rich in flavonoids

Numerous studies have shown that palo azul is rich in flavonoids, which are natural antioxidant compounds found in plants, vegetables, fruits and tea. A 2021 study even mentions that several types of phytonutrients have been identified in palo azul including "flavonoids, polyphenols, phenolic compounds, flavones, flavanones, isoflavones chalcones and dihydrochalcones." 

foods rich in polyphenols and flavonoidsFortunately for us, thousands of studies have shown that flavonoids are antioxidant, anti-inflammatory, anti-diabetic, anti-aging, anti-hypertensive and anti-mutagenic.

For example, a 2014 study mentioned that “numerous epidemiological studies show an inverse correlation between dietary flavonoid consumption and chronic degenerative diseases, such as cardiovascular diseases, diabetes, osteoporosis, neurodegenerative diseases, and cancers.”

2018 study explains the biological mechanisms of palo azul's effects on diabetes: 

"Chalcones, flavonoids, and dihydrochalcones in palo azul promote pancreatic β-cell survival, insulin secretion-enhanced hyperglycemia, and hyperlipidemia in glucose-induced diabetic zebrafish. Palo azul extracts showed protection of the pancreatic β-cell line INS-1 against hydrogen peroxide-induced oxidative injuryThese findings suggest that EP (palo azul) could be used to prevent the development of diabetes.”

Flavonoid-rich foods: apples, pears, onions, strawberries, blueberries, celery, peppers, and teas

applepearsonionsstrawberries and blueberriescelerypalo azul tea cup

Oxidative foodsfoods that are heavily processed and have high fructose content, trans fats and refined carbs

hamburger and fries lead to oxidative stress

medical review which analyzed findings from 161 studies on flavonoids concluded that "oxidative stress may lead to cellular damage which is related to various health ailments such as diabetes, cancer, CVD, neurodegenerative disorders and ageing."

Results from another study concluded that flavonoids in tea “may lower the risk of type 2 diabetes and cardiovascular diseases” and they even have a “beneficial effect on LDL-cholesterol and insulin sensitivity.”

Finally, in a large cohort of women, a 2014 clinical trial has shown that "flavonoids are protective against type 2 diabetes."

Conclusion 

In conclusion, palo azul may have good anti-diabetic potential because it showed the ability to promote healthy levels of blood glucose and insulin sensitivity. The studies found that these beneficial properties are due palo azul's antioxidant activity, and it's flavonoid rich content. Lastly, evidence suggests that these mechanisms could help to inhibit oxidative stress that can negatively impact diabetes markers.

P.S... Don't forget to help your loved ones by sharing palo azul's magic with them!

 

magiktea palo azul logo 
Seems like palo azul really is...
Key for health 😉
 

Clinical Studies

* Palo azul is commonly referred to by its scientific name: Eysenhardtia polystachya / E. polystachya / E.P - Cyclolepis genistoides / C. genistoides - kidney wood - palo dulce

 

(October 2021) Minocycline-Derived Silver Nanoparticles for Assessment of Their Antidiabetic Potential against Alloxan-Induced Diabetic Mice

(May 1, 2018) Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish

(Nov 2013) Cyclolepis genistoides D. Don (palo azul) promotes differentiation of adipocytes and regulates adipokine expression

(July 2016) Ethanol extract of Cyclolepis genistoides D. Don (palo azul) induces formation of myotubes, which involves differentiation of C2C12 myoblast cells

(Winter 2018) The Ethanolic Extract of Eysenhardtia polystachya (Ort.) Sarg. Bark and Its Fractions Delay the Progression of Rheumatoid Arthritis and Show Antinociceptive Activity in Murine Models 

(March 16, 2001) Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia platycarpa

Antioxidant Properties of Wheat Bran against Oxidative Stress

(2013, Feb) Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: review of recent findings.

(2016) (Medical Review: 161 studies) Flavonoids: an overview