Caffeine Free

palo azul caffeine free

We read a bunch of studies and long story short...caffeine actually has many health benefits when consumed in moderation. But just like everything in life, when consumed in excess, it can have some serious negative side effects including insomnia, high blood pressure, anxiety, digestive issues, etc. 

Coffee has been antagonized by several companies who claim to have created replacement beverages with less caffeine which are supposed to be “better for you” because they don’t cause the jitters, anxiety and crash that comes with a good ol’ cup of joe. But is caffeine really that bad for you? Let’s find out.


Firstly, what is caffeine?

why we sleep book

Caffeine is an alkaloid that stimulates the brain by blocking adenosine receptors. Mathew Walker, the author of Why We Sleep, explains that adenosine is like sleep pressure that builds up throughout the day. The more pressure, the sleepier you feel. And when we sleep, the brain removes all that adenosine so we wake up feeling alert and refreshed. 

Walker explains that:

"Caffeine essentially hijacks the adenosine receptors and prevents the signal of adenosine from telling your brain that you’re sleepy. It essentially hits the mute button on adenosine, so it fools ur brain into thinking you haven’t been awake for 12 hours. BUT….that adenosine is still building up, so once you metabolize all the caffeine, you will have a crash from all the adenosine buildup and you’re hit with a huge wave of sleepiness, then you have to have an even stronger cup of coffee to get over that sleepiness. So, we don’t receive the full benefits of deep sleep because we have too much caffeine in our system.”

To illustrate how critical deep sleep is for our health, Walker mentions that after daylight savings, “when we lose 1 hour of sleep, we see a 24% increase in relative heart attack rates the following day. Yet when we gain an hour of sleep, we see a 21% reduction in heart attacks.”

How much is too much caffeine?

The USDA suggests that a daily intake of under 400 mg of caffeine (2-4 cups of coffee) is safe. Most of the studies found that the recommended daily intake is around 200 mg. 


1. Boosts Metabolism

woman running

One study found that “caffeine may increase metabolism by up to 11% and fat burning by up to 13%” and that it “may increase the use of fat as fuel” during exercise. Another study mentions that “caffeine has also been recently linked to weight loss and consequent reduction of the overall risks for developing the metabolic syndrome.”

WebMD wrote an article which mentions that 1 cup of coffee led to a “3-4% increase in metabolic rate” which increases the number of calories burned.


2. Athletic Performance

women weight lifting

A study found that “caffeine increases production of plasma catecholamines that allow the body to adapt to the stress created by physical exercise...thus allowing glycogen sparing.” This essentially means that caffeine is “able to improve physical performance and endurance during prolonged activity of submaximal intensity” because glycogen sparing can prolong the time it takes for muscles to get exhausted. 

We had never heard of this before but apparently it’s legit! Another study found that performance benefits attributed to caffeine include physical endurance, reduction of fatigue, and enhancing mental alertness and concentration. A 2005 study also found that “in comparison to placebo, caffeine reduced RPE (rating of perceived exertion) during exercise by 5.6%” which means that it decreased muscle exhaustion.

Lastly, a 2015 study found that “caffeine augmented resistance exercise performance (total repetitions, volume load) without increasing blood lactate” and concluded the following: “The addition of caffeine increased mean power and velocity of squat performance. These results indicate supplementation with caffeine can enhance local muscle endurance during resistance exercise.”

This basically means that...Workout + Coffee = More gains!


3. Cardiovascular Health

blood pressure meter

Caffeine seems to have a negative reputation when it comes to cardiovascular health because numerous studies have shown that caffeine increases blood pressure [1, 2, 3, 4, 5, 6, 7]. It also doesn’t help that there’s conflicting evidence which finds that caffeine is both beneficial, and detrimental to cardiovascular health. 

One study mentions that “in the past, coffee was often viewed as a cardiovascular risk-factor. However, in recent studies, coffee-consumption was not associated with risk of coronary heart disease.” But another study found that “caffeine consumption increases the risk of coronary heart disease, arterial hypertension, arterial stiffness, and an elevation of cholesterol and homocysteine plasma concentration.” And another study found that “coffee-consumption resulted in small increases in blood pressure and increased circulating LDL cholesterol and triglycerides concentrations.”

A 2013 study found that “coffee consumption may reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with cardiovascular risk such as obesity and depression. Moreover, large epidemiological studies suggest that regular coffee drinkers have reduced risks of mortality, both cardiovascular and all-cause.” However, the authors mention that “most of the data on coffee's health effects are based on observational data, with very few randomized, controlled studies, and association does not prove causation.” Lastly, they concluded that the benefits must be “weighed against potential risks including anxiety, insomnia, tremulousness, and palpitations, as well as bone loss and possibly increased risk of fractures.”

Some studies mention that although caffeine increases blood pressure in the short term, the body develops a tolerance which doesn’t affect blood pressure in the long term. But one study mentioned that “caffeine may therefore cause persistent BP effects in persons who are regular consumers.” 

Another study even concluded that regular coffee may be harmful to some hypertension-prone subjects. But a recently published 2021 study concluded the following: 

“The results of numerous studies and meta-analyses indicate that moderate coffee consumption (1-3 cups / day) does not increase and may even reduce the risk of developing arterial hypertension. Moderate habitual coffee consumption in hypertensive persons does not appear to increase the risk of uncontrolled blood pressure and may even reduce the risk of death from any cause.”

dog raising hand question

So which is it? The conflicting evidence is probably due to the fact that caffeine has an acute effect of raising blood pressure in the short term, but not in the long term. One research paper explains that the “discrepancy could be explained by an acute adverse effect of coffee, rather than a long-term adverse effect.”

Although caffeine consumption is unlikely to lead to cardiovascular disease, it is important to maintain moderation because it does increase blood pressure and cholesterol and there have been a few cases of fatal caffeine overdoses. 

Side Effects

1. Disrupts Sleep Quality

woman sleeping bad

A 2016 study says that “the data suggests that shorter sleep is associated with greater caffeine consumption.” Another study recommends not consuming caffeine at least 6 hours prior to sleep because they found that “caffeine taken 6 hours before bedtime has important disruptive effects on sleep.”

The Mayo Clinic also mentions that caffeine taken in the afternoon can interfere with your sleep, which can affect your alertness the next day...causing you to drink more caffeine to stay alert and further affecting your sleep in a vicious cycle

This claim is supported by a 2008 clinical review which mentions that “population-based studies indicate that regular daily dietary caffeine intake is associated with disturbed sleep and associated daytime sleepiness.” 

But in case you’re anything like the NAVY SEALs and you’re in situations of sleep deprivation...a study randomly assigned 100-400 mg caffeine or a placebo to SEAL trainees after 72 hours of sleep deprivation and found that “200-300 mg caffeine significantly improved visual vigilance, choice reaction time, repeated acquisition, self-reported fatigue and sleepiness with the greatest effects on tests of vigilance, reaction time, and alertness.


2. Anxiety

woman with anxiety

Although caffeine’s stimulatory effects are beneficial for alertness and focus, Healthline mentions higher doses of caffeine can “lead to anxiety and nervousness. Extremely high daily intakes of 1,000 mg or more per day have been reported to cause nervousness, jitteriness and similar symptoms in most people.

​​A 2015 review found that consuming over 400 mg of caffeine per day led to the following side effects: a fast heartbeat, anxiety, agitation, restlessness, sleeping problems, tremors. This is supported by another study which found that caffeine increased anxiety, depression, and hostility.” Lastly, a cross sectional study of 4558 Australians found “that the proportion of subjects reporting indigestion, palpitations, tremor, headache and insomnia increased significantly with mean caffeine intake.”


3. Digestive Issues

woman with digestive issues

A 2009 study found that “there was an association between the use of caffeine-containing substances (coffee and kola nuts) and the prevalence of gastroesophageal reflux disease.” Another study mentions that “caffeine stimulates gastric acid secretion and reduces the competence of the lower esophageal sphincter in man” so it’s not recommended for people with digestive issues. 

Healthline mentions that although moderate consumption of caffeine can be beneficial for digestive health, larger doses “may lead to loose stools and GERD (Gastroesophageal reflux disease). Lastly, one study found that “caffeine 3.5 mg/kg affected esophageal function, which is known to promote the reflux of gastric contents up into the esophagus.” That doesn’t sound pretty!


4. Pregnancy

woman pregnant

A dose-response analysis found that “each 100-mg/day increment in maternal caffeine intake (1 cup of coffee) was associated with 13% higher risk of low birth weight.” This study concluded that “higher maternal caffeine intake during pregnancy was associated with a higher risk of delivering low birth weight infants.” 

For this reason, the American College of Obstetricians and Gynecologists, recommends that “pregnant women should limit their daily intake to 200 mg.” The Mayo Clinic also wrote an article which recommends that pregnant women and those who are breast feeding should limit their daily caffeine intake to 200 mg. 


5. Excessive Urination


One study found that “caffeine at 4.5 mg/kg caused diuresis” (urination). The authors also mention thatcaffeine can promote early urgency and frequency of urination” and they recommend that “individuals with lower urinary tract symptoms should avoid or be cautious in consuming caffeine.”

Another study found that caffeine consumption “is associated with a modest increase in incidence of frequent urgency incontinence” (loss of bladder control). If you feel like you have to go #1 too much, try cutting back on caffeine and see if it helps. 


6. Addiction

people addicted

The Healthline article mentions that although caffeine triggers certain brain chemicals similarly to the way cocaine and amphetamines do, it does not cause classic addiction the way these drugs do. One study found that “daily users had greater increases in headaches, fatigue and other withdrawal symptoms than non-daily users.” WebMD mentions that “failing to consume caffeine one day can lead to withdrawal symptoms like headaches.”

Medical News Today wrote an article which says that caffeine activates many of the same behavioral and neuropharmacological mechanisms that are activated by other drugs of abuse. For this reason, a small percentage of the population develops caffeine use disorder.” They also mention that “some people could become physically dependent on caffeine” and withdrawal symptoms could include “headache, tiredness, reduced energy and alertness, sleepiness, low mood, concentration problems, irritability.”

While caffeine isn’t as addictive as some illegal drugs, it certainly is addictive both physically and psychologically as demonstrated from the withdrawal effects it can have on the body. One way to combat this is by ridding yourself of caffeine dependency by not drinking caffeine everyday. Try it out for a few days and perhaps you’ll find that you’ll be just fine without caffeine. 


7. Toxicity and Overdose

toxic mushroom

Studies have shown that “excessive caffeine intake can cause arrhythmias, hypertension, dehydration, sleeplessness, nervousness, and in rare instances, rhabdomyolysis.” Rhabdomyolysis is a breakdown of muscle tissue that releases a damaging protein (myoglobin) into the blood which damages the kidneys and the heart and can be fatal. 

A 2007 study which corroborates these claims found that caffeine “taken in higher doses can cause serious toxicity and complications like rhabdomyolysis and acute renal failure, which are life threatening.” Lastly, one study documented a case of a 44 year old woman presented with nausea, vomiting, palpitations, and tea-colored urine 6 h after drinking a liter of black coffee containing approximately 565 mg.


In summary, 100-200 mg caffeine (1-2 cups of coffee) can be beneficial for boosting metabolism, increasing athletic performance, and reducing the risk of cardiovascular disease. And most of the negative side effects are only caused by excessive consumption of caffeine (400 mg+).

So you don’t have to feel bad about drinking coffee (as long as it’s not loaded with sugar)! The key is to have balance and moderation. Just listen to your body and see how you feel. 


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When you feel like it's time for a caffeine break...

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(2021) Coffee and Arterial Hypertension

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(2009) Gastroesophageal Reflux Disease: A Population Based Study

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