Palo Azul Detox

palo azul tea detox fruits

13 Medical studies show that Palo Azul can Detox your body

Palo azul’s anti-inflammatory and antioxidant capabilities are among its best known and most studied benefits. We reviewed 13 different medical studies whose results concluded that palo azul exhibited anti-inflammatory, anti-oxidant activity or anti-glycative activity

 

¿What are antioxidants?

palo azul and antioxidant fruits

Antioxidants are compounds such as vitamins or phytochemicals (carotenoids or flavonoids) that inhibit oxidative stress. They protect the tissue from free radical damage and because of this, prevent inflammation in the body.

What is oxidative stress?

oxidative stress

Oxidative stress is an imbalance between free radicals and antioxidants in the body.

What are free radicals?

Free radicals are atoms with a single valence electron that cause damage to the body associated with diabetes, cancer, aging, atherosclerosis, Parkinson's, Alzheimer's and many other diseases.

free radicals and oxidative stress formation

This happens because electrons like to be in pairs... and for this reason, free radicals look for "free" electrons in the body. This causes damage to cells, proteins, DNA and these damaged molecules can mutate, grow tumors, and damage the DNA code. Eventually, this cellular damage causes new cells to grow with defects and it will lead to aging and degenerative diseases. 

What are anti-inflammatories? 

Anti-inflammatories are precursors of molecules responsible for signaling out the resolution of inflammation. In other words, they reduce inflammation by blocking inflammatory signals.

For example, Omega-3s are anti-inflammatory, and without them, we have less ability to fight inflammation due to our inability to block inflammatory signals.

omega 3 antiinflammatories

How can you avoid inflammation and oxidative stress in your body?

Here is a short list of anti-inflammatory / antioxidant foods you should eat and a general list of pro-inflammatory / oxidative foods you should reduce in your diet.

Antiinflammatory and antioxidant foods: vegetables, fruits, nuts, seeds, fatty fish, olive oil, turmuric, cocoa and teas such as palo azul

palo azul and antiinflammatory foods

Inflammatory and oxidative foodsfoods that are heavily processed and have high fructose content, trans fats and refined carbs

hamburger and fries lead to oxidative stress

 

Have you ever heard of anti-glycation or AGEs?

AGEs are harmful compounds that are considered to play an important role in the process of aging and in degenerative diseases such as diabetes, cancer, Alzheimer’s, Parkinson’s, cardiovascular disease and others. Studies have shown that palo azul tea possesses anti-glycation properties which inhibit AGEs formation.

 

palo azul antioxidant

Palo Azul vs Oxidative Stress

7 different studies showed that palo azul possesses considerable antioxidant activity, protects against oxidative injury and inhibits oxidative stress.

5 different studies concluded in their results that palo azul reduced or inhibited the formation of AGEs (advanced glycation end products).

4 different studies suggested that palo azul’s anti-glycation ability could be used to prevent diabetes complications.

Some of these studies found compounds in palo azul such as flavonoids, methanol and dihydrochalcone, which induce an anti-inflammatory and/or antioxidant effect.

One particular study stated the following: “Our results in this experiment showed that palo azul has an antidiabetic, antihyperlipidemic, and significant ability to reduce the formation of AGEs and antioxidant activities, which are considered to play important roles in the development of diabetes complications.”

Another study found that “treatment with dihydrochalcone (a powerful ant-glycation compound isolated from palo azul) protects renal function and prevents kidney injury.”

One study done on zebrafish embryos stated that “methanol extract of Eysenhardtia polystachya (palo azul) provides “an effective defense against oxidative stress in zebrafish embryos.”

 

palo azul anti-inflammatory

Palo Azul vs Inflammation

6 different studies concluded in their results that palo azul induced a significant inhibition of inflammation and/or showed anti-inflammatory activity.

Several studies show that “flavonoids in palo azul act as anti-inflammatory agents.”

One study in particular found that a palo azul extract and its rich-flavonoids fractions “inhibited secondary inflammatory reactions in arthritic rats.” 

palo azul joint pain

Another study concluded that palo azul is "effective for chronic inflammation and acute inflammation.”

Other studies found that palo azul ameliorated markers of inflammation and that it “exerted in-vitro anti-inflammatory effects by decreasing production of H2O2 and IL-6.”

How can antioxidants help you?

    They help you lose weight

    woman losing weight with palo azul

    One study analyzed 2754 twins and found that the group that consumed the most flavonoids:

    • Had less percentage of fat
    • Burned more fat in the abdomen

    Specifically, the researchers found that the twins with the highest consumption of flavonoid-rich foods (onions, tea, apples, pears, and cocoa) “had a 3-9% lower FMR (fat mass ratio) than that of their co-twins.”

    Moreover, the researchers found that the “women who ate a lot of flavonoid-rich foods had a lower percentage of body fat than women who ate less. The amount of abdominal fat also differed significantly between the two groups.”

    The researchers of this study also point out that “It is important to note that abdominal fat is an important risk factor for diseases such as type 2 diabetes and heart problems.”

    girl losing weight palo azul
     

    Another study looked at 124,000 people and found that "flavonoids increase energy expenditure, decrease fat absorption and function as anti-inflammatories. The researchers in this same study found that "increased consumption of most flavonoid subclasses was associated with reduced weight gain.” 

    They also mentioned that the participants that consumed more flavonoids maintained their weight better and even lost some weight and they concluded the following:

    "Our results suggest that choosing fruits and vegetables that are high in flavonoids, such as apples, pears, berries and peppers, can help with weight control." 

     

     

    They promote skin health

    woman with antioxidant skin cream
     

    Victoria Lewis, a doctor of dermatology mentions that “antioxidants are often considered the fountain of youth by skin-care professionals and experts.”

    “Not only do they (antioxidants) scavenge free radicals—the number one skin-aging culprits—to promote a brighter, more even complexion, they’re also the superstars at nixing fine lines and keeping skin looking fresh.”

    This is due to its ability to eliminate oxidative stress and free radicals, which are “the number one skin-aging culprits.” 

    This oxidative stress causes damage to our cells, and this damage  eventually leads to aging and wrinkles in our skin. 

    Another doctor of dermatology, Dr. Mack, writes that “antioxidants protect your skin from this (oxidative stress) and help reduce pigmentation and fine lines and wrinkles.” He goes on to mention that in his opinion, “an antioxidant serum is a must for your skin-care routine.”

    For this reason, many pharmaceutical and cosmetic companies supplement their skin care products with tea extracts!

     

     

    "Decrease cancer promoting action"

    palo azul vs cancer

    We read two medical reviews composed of findings from 327 studies done specifically on flavonoids, and found that oxidative stress can lead to cancer, diabetes, cardiovascular disease, and aging ... For this reason, they found that antioxidants show potential to fight these diseases. 

    Therefore, diets rich in antioxidants decrease the cancer-promoting action of free radicals and oxidative stress. One of the studies we reviewed found that fruits and vegetables that have flavonoids have been reported as cancer chemopreventive agents and are inversely associated with cancer incidence.

    *Here’s a very interesting fact for wine drinkers: “Moderate wine drinkers also seem to have a lower risk to develop cancer of the lung, endometrium, esophagus, stomach, and colon.”

    Thank you flavonoids!

    wine reduces risk of cancer

    We also read a study that recruited 1522 breast cancer cases and 1547 frequency control subjects from June 2007 to July 2018 in Guangdong, China. The results of this study indicated that consumption of “flavonoids and most flavonoid subclasses intakes were inversely associated with breast cancer risk.”

    Finally, “the critical relationship of fruit and vegetable intake and cancer prevention has been thoroughly documented. It has been suggested that major public health benefits could be achieved by substantially increasing consumption of these foods.”

    In other words... oxidation in our body leads to cancer and other diseases, therefore we should consume lots of antioxidants to stay healthy.


    palo azul flavonoids

    Flavonoids

    By this point you're probably dying to know... What the heck are flavonoids!?

    Flavonoids are natural products found in vegetables, fruits, plants, bark, flowers, wine and teas like palo azul.

    There’s been hundreds of studies that have found a ton of health benefits which are attributed to their antioxidant, anti-inflammatory, anti-diabetic, anti-aging, anti-hypertensive, anti-bacterial, anti-mutagenic, anti-viral and anti-cancer properties.

     
    palo azul and fruits with flavonoids

    For example, numerous epidemiological studies show an “inverse correlation between dietary flavonoid consumption and chronic degenerative diseases, such as cardiovascular diseases, diabetes, osteoporosis, neurodegenerative diseases, and cancers.”

    According to a medical review, flavonoids’ powerful health benefits have made them “an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications.

    These are the most flavonoid-rich foods: apples, pears, onions, strawberries, blueberries, celery, peppers, and teas such as palo azul

    applepearsonionsstrawberries and blueberriescelerypalo azul tea


    We think this might be the healthiest compound on planet Earth!


    How can flavonoids help you?

    Lower your cholesterol

    eggs cholesterol
     

    One study done on flavonoids  concluded that “flavonoids in tea may lower blood cholesterol concentrations and blood pressure, thereby providing some protection against cardiovascular disease.”

    Another study found that the antioxidant property of flavonoids " inhibits the oxidation of LDL cholesterol.”

    Finally, another study concluded that: “Palo azul (EP) reduced the blood glucose, increased serum insulin, body weight, marker enzymes of hepatic function, glycogen, HDL, GK and HK while there was reduction in the levels of triglyceride, cholesterol.”



    Reduce risk of cardiovascular disease

    palo azul vs cardiovascular disease

    Epidemiological, clinical and animal studies reveal that “flavonoids may exert protective effects against various disease conditions including cardiovascular disease and cancer.”

    Other population studies have demonstrated that “flavonoid intake is inversely correlated with mortality from cardiovascular disease.”

    Researchers also found that flavonoids maylower blood cholesterol concentrations and blood pressure, thereby providing some protection against cardiovascular disease.”

    Finally, a study concluded the following:

    "Antioxidant, antithrombotic, anti-inflammatory, and hypolipidemic properties play a significant role in the lower cardiovascular mortality illustrated by increased flavonoid consumption.”

    Reduce risk of atherosclerosis

    butter atherosclerosis

    Various epidemiological studies show that “flavonoids in tea may lower blood cholesterol concentrations and blood pressure, thereby providing some protection against cardiovascular disease.”

    This is due to its ability to "inhibit the oxidation of LDL through a mechanism involving the elimination of free radicals that plays a key role during atherosclerosis.”

    One study established the importance of the oxidation of LDL cholesterol by writing that “oxidative modification of LDL cholesterol is thought to play a key role during atherosclerosis.”

    *Here comes an extremely important finding!

    Scientists in one study observed the “consumption of them (flavonoids) is associated with improvement in endothelial function (blockage of arteries) via vascular endothelial nitric oxide synthase and protein kinase B (Akt) activation.”


    What is endothelial function?

    The endothelium is a thin membrane that lines the inside of the heart and blood vessels. Endothelial cells release substances that control vascular relaxation and contraction, as well as enzymes that control blood clotting, immune function, and platelet adhesion.

    palo azul vs endothelial dysfunction or clogged arteries
     

    Endothelial dysfunction has been shown to be important in predicting stroke and heart attacks due to the inability of the arteries to dilate completely. Dysfunction can result from high blood pressure, diabetes, high cholesterol, and smoking.

    Studies have shown that endothelial dysfunction precedes the development of atherosclerosis, a chronic disease characterized by abnormal thickening and hardening of the artery walls. This can cause a stroke or a heart attack.

    In other words...Endothelial dysfunction causes a blockage in the arteries that can lead to hypertension, stroke, or heart attack. This is why you should take care of your cholesterol levels by consuming flavonoid-rich foods and eliminating inflammatory and oxidative foods.


    How to avoid oxidative stress and inflammation in your body

    We already shared a list of flavonoid-rich foods which you should definitely include in your diet. The following are some of the most powerful anti-inflammatory and antioxidant foods on the planet.

    Antiinflammatory and antioxidant foods: vegetables, fruits, nuts, seeds, fatty fish, olive oil, turmuric, cocoa and teas such as palo azul

    palo azul and antiinflammatory foods

    Inflammatory and oxidative foodsfoods that are heavily processed and have high fructose content, trans fats and refined carbs

    hamburger and fries lead to oxidative stress


    Reduce your risk of Hypertension

    man with hypertension
     

    We’ve read two medical reviews composed of findings from 327 different studies conducted specifically on flavonoids, and their findings revealed that "dietary flavonoids are associated with a lower risk of hypertension and CVD (cardiovascular disease).”

    The scientists who published these reviews also observed that “the blood pressure level was reduced in patients with hypertension” after greater consumption of flavonoids. 

    Finally, one study concluded the following: “Flavonoids in tea may lower blood cholesterol concentrations and blood pressure, thereby providing some protection against cardiovascular disease.”



    Reduce your risk of Alzheimer, Parkinson, or Dementia

    man with alzheimers parkinsons or dementia
     

    A clinical study analyzed a group of 49,281 men and 80,336 women in the Health Professionals Follow-up Study and found that “the participants in the highest quintile of total flavonoids had a 40% lower PD (Parkinson’s Disease) risk than those in the lowest quintile.” The researchers from this study concluded the following:

    “Our findings suggest that intake of some flavonoids may reduce PD (Parkinson's Disease) risk.”

    Another study found that flavonoids have “favourable biochemical and antioxidant effects associated with various diseases such as cancer, Alzheimer's disease (AD), atherosclerosis, etc.”

    FInally, a study concluded the following: “Flavonoids contained in berries may have a positive effect against Parkinson's disease and may help to improve memory in elderly people. Intake of antioxidant flavonoids has been inversely related to the risk of incidence of dementia.”



    Reduce risk of erectile dysfunction

    man with erectile dysfunction

    Results from one study "showed that “flavonoid consumption 50 mg/day reduced the risk of erectile dysfunction by 32%.” 

    Another study found similarly that "flavonoid-rich foods are associated with a reduced incidence of erectile dysfunction.” 

    Additionally, one study found that "men with erectile dysfunction reported a lower monthly average of total flavonoid intake." 

    Due to the antioxidant capacity of flavonoids, another study concludes that flavonoids "may ameliorate erectile dysfunction by inhibiting oxidative stress."

     


    How can anti-inflammatories help you?

    Reduce sciatic nerve pain

    palo azul sciatic nerve health


    The main cause for sciatic nerve pain is commonly caused by the accumulation of uric acid in the blood and palo azul is an active reducer of uric acid levels. Inflammation is another common cause of sciatic nerve pain and we have already discovered that palo azul is a powerful anti-inflammatory. For these 2 reasons, palo azul has been traditionally used for centuries to treat sciatic nerve pain and also joint pain.

    One medical study concluded the following: The inhibition (of inflammation) leads to a reduction in pain behavior and inflammation following chronic constriction injury (CCI) of the sciatic nerve.

    Another medical article mentions that “any cause of irritation or inflammation of the sciatic nerve can produce the symptoms of sciatica.”

    In addition to this, one study found mentions that “the plant (palo azul) has been used in traditional treatments of nephrolithiasis or urolithiasis [2], lumbalgia, arthritis, rheumatism, sciatica, and as blood depurative because it eliminates uric acid, of which application the palo azul derives its diuretic and antirheumatic fame.”

     


    Reduces back pain and arthritis

    woman with back pain

    Various studies have found that flavonoids and palo azul’s antiinflammatory capacities are effective for treating arthritis and pain management.

    One study found that “palo azul and its flavonoids-rich fractions inhibited secondary inflammatory reactions in arthritic rats” and that “many plant constituents, including flavonoids, have proven effective against arthritis.”

    Another study mentions that many plant constituents, including flavonoids, have proven effective against arthritis by reducing cartilage degradation, diminishing leukocyte infiltration in the synovial space, decreasing serum cytokine levels, and other mechanisms (9).“

    Finally, one study concluded the following: “Our findings support the use of Eysenhardtia polystachya bark (palo azul) for the treatment of rheumatoid arthritis and pain management.”




    Strengthens joints

    palo azul strengthens joint health

    A common cause of joint pain is inflammation, and we already know that palo azul is a powerful anti-inflammatory.

    In addition to this, a study found that flavonoids (found in vegetables, fruits and teas like palo azul) “have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D.”

    This finding is supported by population studies whichecent have shown “flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption.”

     

     magiktea palo azul logo

    Seems like palo azul and its mighty flavonoids really are...
    key for health ;)

     

     

    Medical Studies

    * Palo Azul is commonly referred to by its scientific name: Eysenhardtia polystachya / E. polystachya / E.P - Cyclolepis genistoides / C. genistoides - kidney wood - palo dulce

     

    (Apr-Jun, 2014) Evaluation of antidiabetic, antioxidant and antiglycating activities of the Eysenhardtia polystachya

    (Sept 8, 2018) Silver Nanoparticles Synthesized Using Eysenhardtia polystachya and Assessment of the Inhibition of Glycation in Multiple Stages In Vitro and in the Zebrafish Model 

    (June 8, 2016) Properties of Flavonoids Isolated from the Bark of Eysenhardtia polystachya and Their Effect on Oxidative Stress in Streptozotocin-Induced Diabetes Mellitus in Mice

    (Winter 2018) The Ethanolic Extract of Eysenhardtia polystachya (Ort.) Sarg. Bark and Its Fractions Delay the Progression of Rheumatoid Arthritis and Show Antinociceptive Activity in Murine Models

    (May 1, 2018) Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish 

    (Dec 1, 2011) SEPARACIÓN Y EVALUACIÓN DEL EFECTO ANTIINFLAMATORIO Y ANTIOXIDANTE DE LOS FLAVONOIDES DE Eysenhardtia polystachya (Ort.) Sarg.

    (March 28, 2019) 3-O-β-d-glucopyranosyl-α,4,2,4,6-pentahydroxy-dihydrochalcone, from Bark of Eysenhardtia polystachya Prevents Diabetic Nephropathy via Inhibiting Protein Glycation in STZ-Nicotinamide Induced Diabetic Mice 

    (Summer, 2018) Silver nanoparticles synthesized with a fraction from the bark of Eysenhardtia polystachya with high chalcone and dihydrochalcone content effectively inhibit oxidative stress in the zebrafish embryo model

    (Winter 2018) The Ethanolic Extract of Eysenhardtia polystachya (Ort.) Sarg. Bark and Its Fractions Delay the Progression of Rheumatoid Arthritis and Show Antinociceptive Activity in Murine Models 

    (Feb 29, 2015) Evolution of anti-inflammatory activity of the bark of Eysenhardtia polystachia in experimental animal models 

    (May 25, 2011) Anti-inflammatory properties from isolated compounds of Cyclolepis genistoides 

    (Oct, 2018) Pharmacological and toxicological study of a chemical-standardized ethanol extract of the branches and leaves from Eysenhardtia polystachya (Ortega) Sarg. (Fabaceae) 

    (2010) Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury

    (2019) Sciatica Nerve Pain

    (2008) Development of a capillary electrophoresis method for the characterization of “palo azul” (Eysenhardtia polystachya)

     

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