Palo Azul vs Sciatic Nerve Pain

woman with sciatic nerve pain

Studies show 2 reasons why palo azul is key for relieving sciatic nerve pain

One of the lesser known benefits of palo azul is that it can improve sciatic nerve health. The main reason for this is that sciatic nerve pain is commonly caused by an accumulation of uric acid in the blood, and palo azul is an active reducer of uric acid levels. 

Inflammation is another common cause of sciatic nerve pain and many studies have proven palo azul’s powerful anti-inflammatory activity. For these 2 reasons, palo azul has been traditionally used to treat sciatic nerve pain for centuries!

Here's a list of some of the most anti-inflammatory foods: vegetables, fruits, nuts, seeds, fatty fish, olive oil, turmeric, cocoa and teas such as palo azul

palo azul and antiinflammatory foods

Uric Acid Reducer

One study mentions that “the plant (palo azul) has been used in traditional treatments of nephrolithiasis or urolithiasis [2], lumbalgia, arthritis, rheumatism, sciatica, and as blood depurative because it eliminates uric acid, of which application the palo azul derives its diuretic and antirheumatic fame.”

Another study found that uric acid indices were significantly higher in the group of diabetic mice that did not receive the blue stick extracts compared to the control group.

This same study concluded the following: Groups treated with 25, 50, and 100 mg/kg of the dihydrochalcone (palo azul extract) showed a significantly decreased (p < 0.05) uric acid.”


Six different studies concluded in their results that palo azul induced a significant inhibition of inflammation and/or showed anti-inflammatory activity. Moreover, several studies show that “extracts in palo azul act as anti-inflammatory agents.”

omega 3 antiinflammatory

One medical study concluded the following: The inhibition (of inflammation) leads to a reduction in pain behavior and inflammation following chronic constriction injury (CCI) of the sciatic nerve.

palo azul joint health

Another medical article mentions that “any cause of irritation or inflammation of the sciatic nerve can produce the symptoms of sciatica.”

Hundreds of studies have shown that palo azul and its flavonoids are powerful anti-inflammatories and because of this property, their ability to calm joint pain has been demonstrated.


palo azul flavonoids


In addition to the palo azul's ability to inhibit inflammation and reduce uric acid levels, it also contains one of the healthiest compounds in the world!

You can learn all about flavonoids on our Benefits page, but for now just know that there are hundreds of studies that have shown that they have anti-inflammatory, anti-oxidant, anti-aging properties, etc.

In fact, one study found that flavonoids (found in vegetables, fruits and teas like palo azul) “have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D.”

palo azul strengthens joint health

This finding is supported by population studies which have shown “flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption.”

These are some of the most flavonoid-rich foods: apples, pears, onions, strawberries, blueberries, celery, peppers, and teas such as palo azul

applepearsonionsstrawberries and blueberriescelerypalo azul tea


Several studies have also shown that palo azul has antinociceptive properties. What does this mean? Antinociceptives block the detection of a painful or harmful stimulus by sensory neurons. 

In other words... they inhibit the sensation of pain by blocking signals from neurons. Popular examples of antinociceptives include general anesthesia and morphine.

palo azul antinociceptive

One study mentioned that palo azul “decreased the serum levels of pro-inflammatory cytokines and showed antinociceptive activity. These findings support the use of Eysenhardtia polystachya in Mexican folk medicine for treating rheumatoid arthritis and pain management.

Here's an interesting finding: Another study found that palo azul “showed antinociceptive and antidiarrheal effects with similar potency compared to standard drugs.”

* Although we do not recommend replacing standard medications, these findings establish the importance of having a diet full of natural medicines with potent health benefits. 

palo azul and fruits with flavonoids

For all these reasons palo azul has been used traditionally for centuries to treat conditions such as arthritis, rheumatism, lumbago, gout and sciatica.

Below, we have summarized the key points of all the medical studies we have analyzed and also cited all the scientific literature.

P.S...Don't forget to share palo azul's magic with your loved ones!

book with palo azul benefits and studies

Key findings from medical studies

• One article states that "the action of this natural medicine decreases uric acid levels in the blood, which is the main factor causing discomfort for these conditions (sciatica).”

• “Medications used in the treatment of sciatica include pain relievers, muscle relaxants, anti-inflammatories, and antidepressants.”

• “We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. Many plant constituents, including flavonoids, have proven effective against arthritis by reducing cartilage degradation, diminishing leukocyte infiltration in the synovial space, decreasing serum cytokine levels, and other mechanisms (9).“

• “Our findings support the use of Eysenhardtia polystachya bark for the treatment of rheumatoid arthritis and pain management.”

• “The results here presented corroborate the folk medicinal use of Eysenhardtia polystachya in the treatment of infections, diarrhea, inflammation, and pain.” 

 magiktea palo azul logo

It seems like palo azul and its mighty flavonoids really are...
key for health ;)


Medical Studies

* Palo Azul is commonly referred to by its scientific name: Eysenhardtia polystachya / E. polystachya / E.P - Cyclolepis genistoides / C. genistoides - kidney wood - palo dulce

(2010) Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury

(2019) Sciatica Nerve Pain

(2008) Development of a capillary electrophoresis method for the characterization of “palo azul” (Eysenhardtia polystachya)

(Winter 2018) The Ethanolic Extract of Eysenhardtia polystachya (Ort.) Sarg. Bark and Its Fractions Delay the Progression of Rheumatoid Arthritis and Show Antinociceptive Activity in Murine Models

(1986) Increased norepinephrine and uric acid levels in the spinal cord of arthritic rats 

(2008) Development of a capillary electrophoresis method for the characterization of “palo azul” (Eysenhardtia polystachya)

(Feb 29, 2015) Evolution of anti-inflammatory activity of the bark of Eysenhardtia polystachia in experimental animal models

(May 25, 2011) Anti-inflammatory properties from isolated compounds of Cyclolepis genistoides 

(Oct, 2018) Pharmacological and toxicological study of a chemical-standardized ethanol extract of the branches and leaves from Eysenhardtia polystachya (Ortega) Sarg. (Fabaceae)